Method for the hydrolysis of substituted formylamines into substituted amines
OwnerMikhail Bobylevinventor
Life of this patent
Estimating the term…
Abstract
An improved method for the synthesis of substituted formylamines and substituted amines via an accelerated Leuckart reaction. The Leuckart reaction is accelerated by reacting formamide or N-alkylformamide and formic acid with an aldehyde or a ketone at a preferred molar ratio that accelerates the reaction. The improved method is applicable to various substituted aldehydes and ketones, including substituted benzaldehydes. An accelerated method for the hydrolysis of substituted formylamines into substituted amines using acid or base and a solvent at an elevated temperature. The improved method is useful for the accelerated synthesis of agrochemicals and pharmaceuticals such as vanillylamine, amphetamine and its analogs, and formamide fungicides.
Claims9
A method for the accelerated hydrolysis of the substituted formylamine into a substituted amine, comprising:
- a. mixing the substituted formylamine with a volume of acid or base and alcohol in sealed reaction system;
- b. raising the temperature of the reaction mixture to a reaction temperature system between 100° C. and 160° C.;
- and
- c. maintaining the mixture to react at the reaction temperature for a time between 0 seconds to 60 minutes.
The method of 1, wherein once the reaction temperature is reached, the heat is turned off.
Dependencies are inferred from the claim text.