Antitumoral compounds

A compound of general formula I

• wherein Y is selected from —CHRay—, —CHRay—CHRby—, —CRay═CRby—, —C≡C—, —CHRay—CHRby—CHRcy—, —CHRay—CRby═CRcy—, and —CHRay—C≡C—;
• each Ray, Rby, and Rcy is independently selected from hydrogen, substituted or unsubstituted C1-C12 alkyl, substituted or unsubstituted C2-C12 alkenyl, and substituted or unsubstituted C2-C12 alkynyl;
• each R1, R2, R3, R4, and R5 is independently selected from hydrogen, substituted or unsubstituted C1-C12 alkyl, substituted or unsubstituted C2-C12 alkenyl, and substituted or unsubstituted C2-C12 alkynyl;
• R6 is selected from NR8R9, and OR10;
• W is selected from O and NR7;
• R7 is selected from hydrogen, CORa, COORa, substituted or unsubstituted C1-C12 alkyl, substituted or unsubstituted C2-C12 alkenyl, and substituted or unsubstituted C2-C12 alkynyl, or R7 and R5 together with the corresponding N atom and C atom to which they are attached may form a substituted or unsubstituted heterocyclic group;
• R8 is selected from hydrogen, CORa, COORa, substituted or unsubstituted C2-C12 alkenyl, substituted or unsubstituted C2-C12 alkynyl, and substituted or unsubstituted C4-C12 alkenynyl;
• R10 is selected from substituted or unsubstituted C2-C12 alkenyl, and substituted or unsubstituted C2-C12 alkynyl;
• each dotted line represents an optional additional bond with the proviso that one or more additional bonds are present, but when a triple bond exists between the C atoms to which R1 and R2 are attached, R1 and R2 are absent, and when a triple bond exists between the C atoms to which R3 and R4 are attached, R3 and R4 are absent;
• R9 is selected from hydrogen, CORa, COORa, substituted or unsubstituted C2-C12 alkenyl, substituted or unsubstituted C2-C12 alkynyl, and substituted or unsubstituted C4-C12 alkenynyl;
• each R11, R12, R13, R14, and R15 are independently selected from hydrogen, halogen, ORa, CORa, COORa, OCORa, OCOORa, OCONRaRb, CONRaRb, OS(O)Ra, OSO2Ra, OP(O)(Ra)ORb, OSiRaRbRc, NRaRb, NRaCORb, NRaCONRaRb, NRaS(O)Rb, NRaSO2Rb, NRaC(═NRa)NRaRb, SRa, S(O)Ra, SO2Ra, S(O)NRaRb, SO2NRaRb, S(O)ORa, SO2ORa, substituted or unsubstituted C1-C12 alkyl, substituted or unsubstituted C2-C12 alkenyl, and substituted or unsubstituted C2-C12 alkynyl;
• and
• each Ra, Rb, and Rc are independently selected from hydrogen, substituted or unsubstituted C1-C12 alkyl, substituted or unsubstituted C2-C12 alkenyl, substituted or unsubstituted C2-C12 alkynyl, substituted or unsubstituted aryl and substituted or unsubstituted heterocyclic group;
• or a pharmaceutically acceptable salt, tautomer, or stereoisomer thereof.