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US 8,710,245 B2Granted
Multicyclic compounds and methods of use thereof
AssigneesPsychogenics, Inc., Sunovion Pharmaceuticals Inc.
InventorsLiming Shao, John Emmerson Campbell, Michael Charles Hewitt, Una Campbell, Taleen G. Hanania
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Abstract
Provided herein are multicyclic compounds, methods of their synthesis, pharmaceutical compositions comprising the compounds, and methods of their use. The compounds provided herein are useful for the treatment, prevention, and/or management of various neurological disorders, including but not limited to, psychosis and schizophrenia.
Claims41
A compound of formula (IVa):
- or a pharmaceutically acceptable salt or stereoisomer thereof, wherein:
- m is 0;
- n is 1;
- R1 and R2 are each independently hydrogen or C1-C4 alkyl;
- R3 and R4 are each independently hydrogen or C1-C4 alkyl;
- R5 is hydrogen;
- and
- R6 and R7 are each independently hydrogen, halo, or C1-C4 alkyl.
5 more elements
Dependencies are inferred from the claim text.