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US 8,710,241 B2Granted
Crystalline form of zofenopril calcium
AssigneeGenerics [UK] Limited
InventorAxel Becker
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Abstract
The present invention relates to a novel anhydrous crystalline form of zofenopril calcium of formula (I), chemically known as (4S)-1-[(2S)-3-(benzoylthio)-2-methylpropionyl]-4-(phenylthio)-L-proline calcium salt or hemi-calcium salt. The present invention further relates to a process for the preparation of the new crystalline form of zofenopril calcium, its use in pharmaceutical compositions and the use of the new crystalline form and compositions in the treatment of hypertension and various other diseases.
Claims16
A zofenopril calcium crystalline form:
- (i) comprising characteristic XRPD peaks at seven or more of 17.7, 18.0, 18.3, 19.2, 19.5, 19.9, 20.5, 21.9 and 23.1±0.2° 2θ;
- and
- (ii) having a DSC heating trace substantially as shown in FIG. 2;
- and/or
- (iii) having a TGA heating trace substantially as shown in FIG. 3;
- and/or
- (iv) having a water vapour sorption isotherm substantially as shown in FIG. 4.
4 more elements
Dependencies are inferred from the claim text.