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US 8,710,227 B2Granted
Crystalline form of (R)-7-chloro-N-(quinuclidin-3-yl)benzo[b]thiophene-2-carboxamide hydrochloride monohydrate
AssigneeEnVivo Pharmaceuticals, Inc.
InventorsPatricia Oliver-Shaffer, Gideon Shapiro, Richard Chesworth, Muneki Kishida, Takayuki Ishige
Life of this patent
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Abstract
Crystalline Forms I and II of (R)-7-chloro-N-(quinuclidin-3-yl)benzo[b]thiophene-2-carboxamide hydrochloride monohydrate and compositions, methods of manufacture and therapeutic uses thereof are described.
Claims24
A crystalline Form I of (R)-7-chloro-N-(quinuclidin-3-yl)benzo[b]thiophene-2-carboxamide hydrochloride monohydrate, characterized by an x-ray powder diffraction pattern having having peaks expressed as 2Θ at:
- i) one or both of 17.48 and 20.58 ±0.20 degrees when measured against an internal silicon standard;
- and
- ii) at least four peaks selected from a group of peaks consisting of:
- 4.50, 9.04, 14.60, 15.14, 15.80, 16.60, 18.16, 18.44, 19.48, 21.74 and 25.46±0.20 degrees when measured against an internal silicon standard.
1 more element
A pharmaceutical composition comprising the crystalline Form I.
Dependencies are inferred from the claim text.