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US 8,710,223 B2Granted
Protein kinase C inhibitors and uses thereof
AssigneeRigel Pharmaceuticals, Inc.
InventorsSacha Holland, Rao Kolluri, Salvador Alvarez, Matthew Duncton, Rajinder Singh, Jing Zhang, Esteban Masuda
Life of this patent
Estimating the term…
Abstract
This disclosure concerns compounds which are useful as inhibitors of protein kinase C (PKC) and are thus useful for treating a variety of diseases and disorders that are mediated or sustained through the activity of PKC. This disclosure also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.
Claims2
A compound of the formula:
- N2-(4-Cyclopropyl-2-fluoro-5-tetrazol-1-yl-phenyl)-5-fluoro-N4-(2,2,6,6-tetramethyl-piperidin-4-yl)-pyrimidine-2,4-diamine (I-12), or a pharmaceutically acceptable salt or stereoisomer thereof.
Dependencies are inferred from the claim text.