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US 8,710,221 B2Granted
Process and intermediates for preparing lapatinib
AssigneeScinoPharm Taiwan, Ltd.
InventorsYung-Fa Chen, Julian Paul Henschke, Xiaoheng Zhang, YiJing Chen, ChunFang Xu, Yong Mu
Life of this patent
Estimating the term…
Abstract
A compound of formula (X): which can be used as an intermediate to make lapatinib or its pharmaceutically acceptable salt.
Claims8
A process for preparing lapatinib or a pharmaceutically acceptable salt thereof comprising converting a compound of formula (X):
- to lapatinib:
- or the pharmaceutically acceptable salt thereof, wherein the step of converting the compound of formula (X) comprises:
- i) reacting the compound of formula (X):
- with a compound of formula (VII):
- in a solvent to produce a compound of formula (IV) or its salt
- and
- ii) reductively aminating the compound of formula (IV) or its salt with a compound of formula (VIII)
- or its salt to provide lapatinib or the pharmaceutically acceptable salt thereof.
5 more elements
A compound of formula (X):
- or a salt thereof.
A process for preparing a compound of formula (X):
- comprising a step of reacting a compound of formula (IX):
- with SOCl2 in the presence of toluene.
Dependencies are inferred from the claim text.