Modulation of HSP47 expression

A double stranded nucleic acid molecule having a structure (A2) set forth below:

• wherein each of N2, N and N′ is independently an unmodified or modified ribonucleotide, or an unconventional moiety;
• wherein each of (N)x and (N′)y is an oligonucleotide in which each consecutive N or N′ is joined to the adjacent N or N′ by a covalent bond;
• wherein each of x and y is 18;
• wherein the sequence of (N′)y has complementarity to the sequence of (N)x and the sequence of (N)x has complementarity to a consecutive sequence in a mRNA encoding hsp47;
• wherein N1 is covalently bound to (N)x and is mismatched to the mRNA encoding hsp47;
• or is a complementary DNA moiety to the mRNA encoding hsp47;
• wherein N1 is a moiety selected from natural or modified uridine or deoxyribouridine;
• wherein z″ may be present or absent, but if present is a capping moiety covalently attached at the 5′ terminus of N2—(N′)y;
• wherein each of Z and Z′ is independently present or absent, but if present is independently 1-5 consecutive nucleotides, consecutive non-nucleotide moieties or a combination thereof covalently attached at the 3′ terminus of the strand in which it is present;
• and
• wherein the sense strand and the antisense strand comprise the oligonucleotides described as SERPINH1—2 (SEQ ID NOS:
• 60 and 127).