Inhibitors of bacterial tyrosine kinase and uses thereof
AssigneeCentre National de la Recherche Scientifique (CNRS)
InventorsChristophe Louis Antoine Grangeasse, Sylvie Marianne Nessler, Solange Rose Theodora Morera, Philippe Roger Meyer, Alain Jean Cozzone, Raphael Terreux
Life of this patent
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Abstract
A compound comprising a peptide moiety comprising, consisting essentially of, or consisting of, the peptide sequence of a tyrosine cluster YC of the BY-kinase of a Gram positive or Gram negative bacteria, or a fragment or an analogue thereof, and an adenine peptide analogue PNA(A), whereas the peptide moiety and the PNA are linked together. The compound is useful as an inhibitor of bacterial tyrosine kinase.
Claims34
A compound comprising a peptide moiety comprising, the peptide sequence of a tyrosine cluster YC of the BY-kinase of a bacteria, or a fragment or an analogue thereof, and an adenine peptide analogue PNA(A), whereas the peptide moiety and the PNA(A) are linked together.
A compound having formula:
- KYGVYGFYGNK(PNA(A))
- (SEQ ID NO:
- 46)
- SYYHYK(PNA(A))
- (SEQ ID NO:
- 47)
- HYGYSYK(PNA(A))
- (SEQ ID NO:
- 48)
- AYSYGYNYYGYSK(PNA(A))
- (SEQ ID NO:
- 49)
- NYGYGYDYYDYSK(PNA(A))
- (SEQ ID NO:
- 50)
- KYGYGYNYYDYSK(PNA(A))
- (SEQ ID NO:
- 51)
- GYGYGYGYNYAYK(PNA(A))
- (SEQ ID NO:
- 52)
- DYGYYEYEK(PNA(A))
- (SEQ ID NO:
- 53)
- SASYYAY K(PNA(A))GTD
- (SEQ ID NO:
- 62)
- ESSYGAY K(PNA(A))GTD
- (SEQ ID NO:
- 63)
- KHSEYGY K(PNA(A))GTK
- (SEQ ID NO:
- 64)
- YNYYGYS K(PNA(A))SEK
- (SEQ ID NO:
- 65)
- KHSEGEY K(PNA(A))ETK
- (SEQ ID NO:
- 66)
- SSSYYHY K(PNA(A))GDE
- (SEQ ID NO:
- 67)
- VYGFYGN K(PNA(A))GKK
- (SEQ ID NO:
- 68)
- KYGVYGFYGNG(PNA(A))
- (SEQ ID NO:
- 54)
- SYYHYG(PNA(A))
- (SEQ ID NO:
- 55)
- HYGYSYG(PNA(A))
- (SEQ ID NO:
- 56)
- AYSYGYNYYGYSG(PNA(A))
- (SEQ ID NO:
- 57)
- NYGYGYDYYDYSG(PNA(A))
- (SEQ ID NO:
- 58)
- KYGYGYNYYDYSG(PNA(A))
- (SEQ ID NO:
- 59)
- GYGYGYGYNYAYG(PNA(A))
- (SEQ ID NO:
- 60)
- or
- DYGYYEYEG(PNA(A))
- (SEQ ID NO:
- 61)
- wherein PNA(A) is an adenine peptide analogue of general formula (XLI):
- wherein:
- R1 and R2 are independently an alkyl substituted with a carboxyl, carbonyl, alcohol or primary amino;
- Wherein PNA(A) is linked to the peptide moiety by formation of a peptide bond with a N-terminal NH2 group or a C-terminal COOH group of Lys or with an amino group in the side chain of Gly.
A compound comprising a peptide moiety comprising the peptide sequence of a tyrosine cluster YC of the BY-kinase of a bacteria, and an adenine peptide analogue PNA(A), whereas the peptide moiety and the PNA are linked together.
A compound comprising a peptide moiety comprising the peptide sequence of a tyrosine cluster YC of the BY-kinase of a bacteria, and an adenine peptide analogue PNA(A), whereas the peptide moiety and the PNA are linked together and the YC is as depicted on SEQ ID NO:15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29 or 30.
A compound comprising a peptide moiety comprising the peptide sequence of a tyrosine cluster YC of the BY-kinase of a bacteria, and an adenine peptide analogue PNA(A), whereas the peptide moiety and the PNA are linked together and the peptide moiety comprises a fragment of at least 4 amino acid residues of the YC as depicted on SEQ ID NO:15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29 or 30.
A compound comprising a peptide moiety consisting essentially of the peptide sequence of a tyrosine cluster YC of the BY-kinase of a bacteria, and an adenine peptide analogue PNA(A), whereas the peptide moiety and the PNA are linked together and the peptide moiety comprises a sequence as depicted on SEQ ID NO:15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29 or 30.
A compound comprising a peptide moiety comprising the peptide sequence of a tyrosine cluster YC of the BY-kinase of a bacteria, and an adenine peptide analogue PNA(A), whereas the peptide moiety and the PNA are linked together and the YC is as depicted on SEQ ID NO:
- 31, 32, 33, 34, 35, 36, 37, or 38.
A compound comprising a peptide moiety consisting essentially of the peptide sequence of a tyrosine cluster YC of the BY-kinase of a bacteria, and an adenine peptide analogue PNA(A), whereas the peptide moiety and the PNA are linked together and the peptide moiety comprises a sequence as depicted on SEQ ID NO:
- 31, 32, 33, 34, 35, 36, 37 or 38.
A compound comprising a peptide moiety comprising the peptide sequence of a tyrosine cluster YC of the BY-kinase of a bacteria, and an adenine peptide analogue PNA(A), whereas the peptide moiety and the PNA are linked together and the peptide moiety comprises moiety comprises a fragment of at least 4 amino acid residues of a sequence as depicted on SEQ ID NO:
- 31, 32, 33, 34, 35, 36, 37 or 38.
Dependencies are inferred from the claim text.