Non-aqueous solution process for the preparation of cross-linked polymers
AssigneeShasun Pharmaceuticals Limited
InventorsKanchivakkam Ramaswamy Govindarajan, Kalpattu Kuppasamy Balasubramanian, S. Bava Bohorudeen, Somasundaram Angalan, Kalivan Neelakandan
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Abstract
The present invention discloses a non-aqueous solution process for making cross-linked polymers. The cross-linked polymers are characterized by a repeat unit that includes at least one amino group. Amino groups can be part of the polymer backbone (e.g., polyethyleneimine), pendant from the polymer backbone (e.g., polyallylamine), or both types of amino groups can exist within the same repeat unit and/or polymer. The present invention discloses more specifically non-aqueous solution cross-linking to prepare Sevelamer and its salts, Colesevelam and its salts.
Claims27
A process for the preparation of a cross-linked polymer or a salt form thereof comprising steps of:
- a) neutralizing an amine acid addition salt polymer to an amine polymer which comprises a repeating unit of formula selected from group consisting of:
- where n is a positive integer, y is an integer of one or more, z is a positive integer of 1, 2 or 3, each of R, R1, R2 and R3, independently, is H or a substituted or unsubstituted alkyl group, and XZ- is an exchangeable negatively charged counterion;
- and
- b) cross-linking said neutralized amine polymer with a cross-linking agent to obtain cross-linked polymer wherein cross-linking is performed in non-aqueous medium.
Dependencies are inferred from the claim text.