Group of amino substituted benzoyl derivatives and their preparation and their use
AssigneeInstitute of Medicinal Biotechnology Chinese Academy of Medical Science
InventorsJian-Dong Jiang, Liyan Yu, Shan Cen, Zhuorong Li, Yanping Li, Jian Xu
Life of this patent
Estimating the term…
Abstract
A group of amino substituted benzoyl derivatives, their preparation and their use. The screening and research on an antiviral drug with hA3G/Vif as a target point proves that the 3-amino benzoyl derivatives not only have the combined activity for the hA3G/Vif, but also have a function of inhibiting replication of viruses. The present invention provides the possible breakthrough progress for the problem of HIV drug resistance, thereby providing a novel clinical antiviral drug which has higher efficiency.
Claims3
A method of treating HIV infection, comprising administration to a subject in need thereof an effective amount of an amino-benzoyl derivative having a structure as shown in Formula (I):
- wherein R1 is a methoxy group;
- R2 is H;
- R3 is methyl, ethyl, isopropyl, or selected from the group consisting of 2-chloroacetyl, 2-fluoroacetyl, 2-bromoacetyl, 2-chloropropionyl, 2-fluoropropionyl, 2-bromopropionyl, acetyl, propionyl, 2-bromobutyryl, methanesulfonamideacyl, trifluoroacetyl and t-butoxyformyl;
- X is NH;
- Y is C;
- R4 is selected form the group consisting of
Dependencies are inferred from the claim text.