Detection and use of low molecular-weight modulators of the cold-menthol receptor TRPM8
AssigneeBASF SE
InventorsThomas Subkowski, Claus Bollschweiler, Jens Wittenberg, Michael Krohn, Holger Zinke
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Abstract
The invention relates to novel modulators of the cold menthol receptor TRPM8, to a method for modulating the TRPM8 receptor using said modulators; to the use of the modulators for induction of cold sensation; and to objects and means produced using said modulators.
Claims20
A method for in-vitro or in-vivo modulation of cold menthol receptor TRPM8 comprising contacting the receptor with a polynuclear organic compound, wherein in a cellular activity test, the compound is a modulator of the Ca2+ ion permeability of a cell that recombinantly expresses a human TRPM8 receptor, and wherein the modulator is selected from the group consisting of the compounds of formulae 1 to 19:
A method for inducing a sensation of coldness in at least one of a human or an animal, the method comprising contacting the human or animal with a polynuclear organic compound, wherein in a cellular activity test, the compound is a modulator of the Ca2+ ion permeability of a cell that recombinantly expresses a human TRPM8 receptor and wherein the modulator is selected from the group consisting of the compounds of formula 1 to 19:
A modulator for a TRPM8 receptor, wherein the modulator is selected from the compounds of formula 1 to 19:
Dependencies are inferred from the claim text.