Triazole derivatives as ghrelin analogue ligands of growth hormone secretagogue receptors

A method for increasing or decreasing growth hormone levels in a mammal or for increasing or decreasing food intake of a mammal comprising:

• administering to a mammal in need of treatment at least one compound according to formula (I):
• wherein:
• R1 and R2 are independently of one another a hydrogen atom or are selected from the group of radicals consisting of alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, aryl, heteroaryl, arylalkyl, heteroarylalkyl, heterocyclyl, heterocyclylalkyl, alkylsulfonyl, arylsulfonyl, and arylalkylsulfonyl;
• wherein said radicals at R1 or R2 are optionally substituted in an alkyl, cycloalkyl, cycloalkylalkyl, aryl, heteroaryl, arylalkyl, heteroarylalkyl, heterocyclyl and/or heterocyclylalkyl group by up to 3 substituents independently selected from the group consisting of halogen, —F, —Cl, —Br, —I, —N3, —CN, —NR7R8, —OH, —NO2, alkyl, aryl, arylalkyl, —O-alkyl, —O-aryl, and —O-arylalkyl;
• R3 is selected from the group of radicals consisting of alkyl, aryl, heteroaryl, arylalkyl, heteroarylalkyl, heterocyclyl, heterocyclylalkyl, -alkyl-O-aryl, -alkyl-O-arylalkyl, -alkyl-O-heteroaryl, -alkyl-O-heteroarylalkyl, -alkyl-O-heterocyclyl, alkyl-O-heterocyclylalkyl, -alkyl-CO-aryl, -alkyl-CO-arylalkyl, -alkyl-CO-heteroaryl, -alkyl-CO-heteroarylalkyl, -alkyl-CO-heterocyclyl, -alkyl-CO-heterocyclylalkyl, -alkyl-C(O)O-aryl, -alkyl-C(O)O-arylalkyl, -alkyl-C(O)O-heteroaryl, -alkyl-C(O)O-heteroarylalkyl, -alkyl-C(O)O-heterocyclyl, -alkyl-C(O)O-heterocyclylalkyl, -alkyl-CO—NH2, -alkyl-CO—OH, -alkyl-NH2, -alkyl-NH—C(NH)—NH2, alkyl-S-alkyl, and alkyl-S—H;
• wherein said radicals are optionally substituted in the aryl, heteroaryl, arylalkyl, heteroarylalkyl, heterocyclyl and/or heterocyclylalkyl group by up to 3 substituents independently selected from the group consisting of halogen, —F, —Cl, —Br, —I, —N3, —CN, —NR7R8, —OH, —NO2, alkyl, aryl, arylalkyl, —O-alkyl, —O-aryl, and —O-arylalkyl;
• R4 is hydrogen;
• R5 is a radical
• a) selected from the group consisting of alkyl, cycloalkyl, cycloalkylalkyl, aryl, heteroaryl, arylalkyl, heteroarylalkyl, heterocyclyl, heterocyclylalkyl, —CO-alkyl, —CO-cycloalkyl, —CO-cycloalkylalkyl, —CO-aryl, and —CO-arylalkyl, wherein said radical from (a) is optionally substituted by up to 3 substituents independently selected from the group consisting of halogen, —F, —Cl, —Br, —I, —N3, —CN, —OH, —NO2, alkyl, aryl, arylalkyl, —O-alkyl, —O-aryl, and —O-arylalkyl;
• or
• b) selected from the group consisting of —CO-heteroaryl, —CO-heteroarylalkyl, —CO-heterocyclyl, —CO-heterocyclylalkyl, wherein said radical from (b) is optionally substituted by up to 3 substituents independently selected from the group consisting of halogen, —F, —Cl, —Br, —I, —N3, —CN, —NR7R8, —OH, —NO2, alkyl, aryl, arylalkyl, —O-alkyl, —O-aryl, and —O-arylalkyl;
• R6 is hydrogen;
• R7 and R8 are independently of one another selected from the group consisting of a hydrogen atom, alkyl, cycloalkyl, and cycloalkylalkyl;
• and
• m is 0;
• wherein * designates a carbon atom of R or S configuration when chiral.