Salts and polymorphs of desazadesferrithiocin polyether analogues as metal chelation agents
AssigneeFerrokin Biosciences, Inc.
InventorsAmy E. Tapper, Hugh Y. Rienhoff, Jr., Stephan D. Parent, Patricia Andres, Jason A. Hanko, Huamin Zhang
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Abstract
Disclosed herein are new salts and polymorphs of desazadesferrithiocin polyether (DADFT-PE) analogues, as well as pharmaceutical compositions comprising them and their application as metal chelation agents for the treatment of disease. Methods of chelation of iron and other metals in a human or animal subject are also provided for the treatment of metal overload and toxicity.
Claims6
A method of treating transfusional iron overload in a subject suffering from transfusional iron overload comprising administering to the subject a therapeutically effective amount of magnesium (S)-2-(2-hydroxy-3-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)phenyl)-4-methyl-4,5-dihydrothiazole-4-carboxylate hydroxide or polymorph thereof, wherein treatment does not include prophylaxis.
A method of treating a condition chosen from beta-thalassemia major, beta-thalassemia intermedia, sickle cell anemia, Diamond-Blackfan anemia, sideroblastic anemia, chronic hemolytic anemias, off-therapy leukemias, bone marrow transplant and myelodysplastic syndrome, comprising administering to the subject a therapeutically effective amount of magnesium (S)-2-(2-hydroxy-3-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)phenyl)-4-methyl-4,5-dihydrothiazole-4-carboxylate hydroxide or polymorph thereof, wherein treatment does not include prophylaxis.
A method of clearing iron overload in vivo comprising administering to a subject in need thereof a therapeutically effective amount of magnesium (S)-2-(2-hydroxy-3-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)phenyl)-4-methyl-4,5-dihydrothiazole-4-carboxylate hydroxide or polymorph thereof.
Dependencies are inferred from the claim text.