Substituted di-arylhydantoin and di-arylthiohydantoin compounds and methods of use thereof

A compound of formula I:

• wherein
• W1 is CN, NO2 or SO2R4;
• W2 is alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl or halogen;
• Z1 is S or O;
• Z2 is S, O or NR4;
• Y1 and Y2 are independently hydrogen, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, arylalkyl, arylalkenyl, arylalkynyl, heteroaralkyl, heterocyclyl, or substituted heterocyclyl;
• or Y1 and Y2 are connected to form a cycle which can be heterocyclic, substituted heterocyclic, cycloalkyl, or substituted cycloalkyl;
• T is nitrogen and can be at any position in the ring;
• R1 is —C1-C8alkyl-NRaRb, —O—C1C8alkyl-NRcRd or —C(O)NReRf,
• where:
• Ra is a C1-C12alkyl and Rb is H or a C1-C12alkyl;
• or Ra and Rb are taken together with the N to which they are attached to form a heterocyclic ring;
• Rc is a C1-C12alkyl and Rd is H or a C1-C12alkyl or Rc and Rd are taken together with the N to which they are attached to form a heterocyclic ring;
• Re and Rf are taken together with the N to which they are attached to form a heterocyclic ring;
• R2 is hydrogen, halo, nitro, alkyl and substituted alkyl and
• R4 is independently H, alkyl, aryl,
• or a pharmaceutically acceptable salt thereof, wherein at least one of (i)-(v) applies;
• W1 is CN;
• (ii) W2 is perhaloalkyl;
• (iii) Z1 is S;
• (iv) Z2 is O;
• (v) Y1 and Y2 are both methyl.

A compound of formula (I):

• wherein:
• W1 Is CN, NO2 or SO2R4;
• W2 is alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl or halogen;
• Z1 is S or O;
• Z2 is S, O or NR4;
• Y1 and Y2 are independently hydrogen, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, arylalkyl, arylalkenyl, arylalkynyl, heteroaralkyl, heterocyclyl, or substituted heterocyclyl;
• or Y1 and Y2 are connected to form a cycle which can be heterocyclic, substituted heterocyclic, cycloalkyl, or substituted cycloalkyl;
• T is carbon or nitrogen and can be at any position in the ring;
• R1 is —O—C1-C8alkyl-NRcRd,
• where:
• Rc is a C1-C12alkyl and Rd is H or a C1-C12alkyl or Rc and Rd are taken together with the N to which they are attached to form a heterocyclic ring;
• R2 is hydrogen, halo, nitro, alkyl or substituted alkyl and
• R4 is H, alkyl, or aryl,
• or a pharmaceutically acceptable salt thereof.