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US 8,710,080 B2Granted
Prodrugs of [4 [4-(5-Aminomethyl-2-fluoro-phenyl)-piperidin-1-yl]-(1H-pyrrolo-pyridin-yl)-methanones and synthesis thereof
AssigneeSanofi
InventorsYong Mi Choi-Sledeski, Gregory B. Poli
Life of this patent
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Abstract
The present invention relates to substituted 2-amino-N-(4-fluoro-3-{1-[1-(alkyl)-1H-indole-3-carbonyl]-piperidin-4-yl}-benzyl)-acetamides (compounds of formula I) compositions thereof, and their use in the treatment of inflammatory diseases.
Claims7
A compound of formula (I):
- wherein,
- X and Y are selected from the group consisting of hydrogen, methyl, fluoro, chloro, trifluoromethyl, methoxy, trifluoromethoxy, morpholin-4-yl-methanone such that not two of the substituents are hydrogen at the same time;
- R1 is H, lower alkyl or substituted alkyl;
- R2 is selected from the group consisting of hydrogen and natural and unnatural amino acids;
- or
- an N-oxide of said compound, a pharmaceutically acceptable salt of said compound, a solvate of said compound or a hydrate of said compound.
3 more elements
Dependencies are inferred from the claim text.