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US 8,710,078 B2Granted
Crystalline solvates of 6-(piperidin-4-yloxy)-2H-isoquinolin-1-one hydrochloride
AssigneeSanofi
InventorsNorbert Nagel, Bruno Baumgartner, Harald Berchtold, Oliver Plettenburg, Dieter Kadereit, Mandy Mohnicke, Simon Gessler, Joachim Tillner
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Abstract
The present invention relates to crystalline solvates of 6-(Piperidin-4-yloxy)-2H-isoquinolin-1-one hydrochloride, processes for their preparation and the use thereof.
Claims21
A crystalline hydrate of 6-(Piperidin-4-yloxy)-2H-isoquinolin-1-one hydrochloride having the formula
- wherein the hydrate contains 1.85 to 2.2 molecules water per molecule.
A crystalline hydrate of 6-(Piperidin-4-yloxy)-2H-isoquinolin-1-one hydrochloride having the formula
- having a reflection in an X-ray powder diffractogram using CuKα1 radiation at 7.7±0.2 degrees 2theta.
Dependencies are inferred from the claim text.