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US 8,710,072 B2Granted
Morphinan compounds
AssigneeConcert Pharmaceuticals, Inc.
InventorsPhilip B. Graham, I. Robert Silverman
Life of this patent
Estimating the term…
Abstract
This invention relates to novel morphinan compounds and pharmaceutically acceptable salts thereof. This invention also provides compositions comprising a compound of this invention and the use of such compositions in methods of treating diseases and conditions that are beneficially treated by administering a σ1 receptor agonist that also has NMDA antagonist activity.
Claims15
A compound of Formula I:
- or a pharmaceutically acceptable salt thereof, wherein:
- R1 is selected from —O—(C2-C4)alkyl, wherein R1 is optionally substituted with one or more deuterium atoms;
- and
- R2 is selected from CH3, CH2D, CHD2, and CD3;
- provided that at least one deuterium atom is present at either R1 or R2.
2 more elements
A compound having the structure:
- or a pharmaceutically acceptable salt thereof, wherein any atom not designated as deuterium is present at its natural isotopic abundance.
A compound having the structure:
- or a pharmaceutically acceptable salt thereof, wherein any atom not designated as deuterium is present at its natural isotopic abundance.
A compound having the structure:
- or a pharmaceutically acceptable salt thereof, wherein any atom not designated as deuterium is present at its natural isotopic abundance.
Dependencies are inferred from the claim text.