Method of treating cancer using a survivin inhibitor
AssigneeThe Trustees of the University of Pennsylvania
InventorsAlan Berezov, Qiang Wang, Ramachandran Murali, Mark I. Greene
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Abstract
Disclosed herein are methods of treating cancer by administering to a patient a small molecule inhibitor of Survivin. Also disclosed herein are methods of inhibiting Survivin dimerization in a patient by administering a compound of formula (I), (II), (III), or (IV). Methods of inducing cell cycle arrest in cancer cells, comprising G2/M stage arrest, in a patient by administering a compound of formula (I), (II), (III), or (IV) are also disclosed. Further disclosed herein are methods of inducing apoptosis in cancer cells in a patient by administering a compound of formula (I), (II), (III), or (IV).
Claims13
A method of treating cancer having Survivin activity comprising administering to a patient in need thereof a small molecule inhibitor of Survivin activity, wherein said small molecule inhibitor of Survivin activity is a compound of formula I or a pharmaceutical acceptable salt thereof
- wherein
- X is hydrogen, halogen, —OH, alkoxy, or C1-C4 linear or branched alkyl;
- and
- R1 is C1-C6 linear or branched alkyl or cycloalkyl or C6-C14 aryl optionally substituted with halogen, nitro, amine or dioxole.
Dependencies are inferred from the claim text.