Method for the treatment, alleviation of symptoms of, relieving, improving and preventing a cognitive disease, disorder or condition
AssigneeAlcobra Ltd.
InventorsRina Yamin, Dalia Megiddo, Yaron Ilan
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Abstract
The present invention provides uses of a salt adduct comprising at least one positively charged moiety being a pyridoxine or a derivative thereof and at least one carboxylated 5- to 7-membered lactam ring, optionally additionally substituted, for the preparation of a medicament for the treatment, alleviation of symptoms of, relieving, improving and preventing a cognitive disease, disorder or condition in a subject. Additionally, the invention provides use of said salt adducts for the preparation of medicaments for the improvement of cognitive functions in a healthy subject.
Claims6
A method for treating a subject with attention deficit/hyperactivity disorder, wherein the subject is not (i) under the influence of alcohol;
- (ii) an alcoholic;
- or (iii) an abstinent alcoholic, said method comprising administering a total per day dose of metadoxine of between 700-3000 mg, wherein the metadoxine is formulated as a combination of slow release and immediate release forms, wherein (a) the slow release form provides for sustained release of the metadoxine for at least 8 hours, and (b) the relative proportion of the slow release metadoxine to the immediate release metadoxine is between about 60:40 and 80:20.
Dependencies are inferred from the claim text.