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AssigneeDaiichi Sankyo Company, Limited
InventorsNarihiro Toda, Rieko Takano, Takeshi Shida, Takahiro Katagiri, Mitsuhiro Iwamoto, Shinji Ashida, Mami Yamazaki
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To find a therapeutic and/or prophylactic agent for gastrointestinal disorders and so on, the agent having excellent activity and high safety. A compound represented by the following general formula (I) or a pharmacologically acceptable salt thereof. In the formula, A represents an optionally substituted phenylene group; B represents an optionally substituted 4- to 10-membered heterocyclic group, an optionally substituted C6-C10 aryl group, or an optionally substituted C3-C10 cycloalkyl group; R1 represents a hydrogen atom or a C1-C3 alkyl group; R2 represents a hydrogen atom or a C1-C3 alkyl group; R3 represents a C1-C6 alkyl group, a C3-C10 cycloalkyl group, a C1-C3 alkoxy C1-C3 alkyl group, or a C1-C3 hydroxyalkyl group; R4 represents a hydrogen atom, a C1-C6 alkyl group, or a halogen atom; n represents an integer of 1 to 4; and X represents methylene, —O—, —NH—, —N(C1-C3 alkyl)-, —C(═O)—, —S—, —S(O)—, —S(O2)—, or a single bond.
A compound selected from the group consisting of:
A compound selected from the group consisting of:
Trans-4-[3-(hydroxymethyl)phenoxy]-N-methyl-N-(3-methyl-4-{[(3S)-3-methylpiperazin-1-yl]methyl}phenyl)cyclohexanecarboxamide or a pharmacologically acceptable salt thereof.
Trans-4-[(2-cyanopyridin-4-yl)oxy]-N-methyl-N-(3-methyl-4-{[(3S)-3-methylpiperazin-1-yl]methyl}phenyl)cyclohexanecarboxamide or a pharmacologically acceptable salt thereof.
Trans-4-{3-[2-(isopropylamino)-2-oxoethyl]phenoxy}-N-methyl-N-(3-methyl-4-{[(3S)-3-methylpiperazin-1-yl]methyl}phenyl)cyclohexanecarboxamide or a pharmacologically acceptable salt thereof.
Trans-4-{3-[(2-hydroxy-2-methylpropoxy)methyl]phenoxy}-N-methyl-N-(3-methyl-4-{[(3S)-3-methylpiperazin-1-yl]methyl}phenyl)cyclohexanecarboxamide or a pharmacologically acceptable salt thereof.
Trans-4-({3-[(2-hydroxy-2-methylpropoxy)methyl]phenyl}amino)-N-methyl-N-(3-methyl-4-{[(3S)-3-methylpiperazin-1-yl]methyl}phenyl)cyclohexanecarboxamide or a pharmacologically acceptable salt thereof.
3-({Trans-4-[methyl(3-methyl-4-{[(3S)-3-methylpiperazin-1-yl]methyl}phenyl)carbamoyl]cyclohexyl}oxy)benzylmethylcarbamate or a pharmacologically acceptable salt thereof.
2-[3-({Trans-4-[methyl(3-methyl-4-{[(3S)-3-methylpiperazin-1-yl]methyl}phenyl)carbamoyl]cyclohexyl}oxy)phenyl]ethylcarbamate or a pharmacologically acceptable salt thereof.
2-[3-({Trans-4-[methyl(3-methyl-4-{[(3S)-3-methylpiperazin-1-yl]methyl}phenyl)carbamoyl]cyclohexyl}amino)phenyl]ethyl methylcarbamate or a pharmacologically acceptable salt thereof.
2-[3-({Trans-4-[methyl(3-methyl-4-{[(3S)-3-methylpiperazin-1-yl]methyl}phenyl)carbamoyl]cyclohexyl}amino)phenyl]ethyl dimethylcarbamate or a pharmacologically acceptable salt thereof.
Dependencies are inferred from the claim text.