N-phenyl-(homo)piperazinyl-benzenesulfonyl or benzenesulfonamide compounds suitable for treating disorders that respond to the modulation of the serotonin 5-HT6 receptor
AssigneesAbbott Laboratories, AbbVie Deutschland GmbH & Co. KG
InventorsAndreas Haupt, Frauke Pohlki, Liliane Unger, Ana Lucia Relo, Karsten Wicke, Min Zhang
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Abstract
The present invention relates to N-Phenyl-(homo)piperazinyl-benzenesulfonyl or benzenesulfonamide compounds of formula I wherein the variables have the meanings given in the claims and the description, pharmaceutical compositions containing them, and their use in therapy. The compounds possess valuable therapeutic properties and are particularly suitable for treating diseases that respond to modulation of the serotonin 5-HT6 receptor.
Claims20
N-Phenyl-(homo)piperazinyl-benzenesulfonyl or benzenesulfonamide compounds of formula I
- the stereoisomers, N-oxides, tautomers and/or physiologically tolerated acid addition salts thereof;
- and the compounds of the formula I, wherein at least one of the atoms has been replaced by its stable, non-radioactive isotope,
- wherein
- X is a bond or NR4;
- R1 is selected from the group consisting of C1-C4-alkyl and fluorinated C1-C4-alkyl;
- R2 is selected from the group consisting of hydrogen and C1-C4-alkyl;
- R3 is selected from the group consisting of hydrogen, halogen, C1-C4-alkyl, fluorinated C1-C4-alkyl, C1-C4-alkoxy and fluorinated C1-C4-alkoxy;
- R4 is selected from the group consisting of hydrogen, C1-C4-alkyl and fluorinated C1-C4-alkyl;
- R5 is a group -A-[O—B]p—O—R7, wherein
- A and B are independently of each other C1-C4-alkylene or fluorinated C1-C4-alkylene;
- R7 is C1-C4-alkyl or fluorinated C1-C4-alkyl;
- and
- p is 0, 1, 2, 3, 4, 5 or 6;
- R6 is selected from the group consisting of halogen, C1-C2-alkyl, fluorinated C1-C2-alkyl, C1-C2-alkoxy and fluorinated C1-C2-alkoxy;
- m is 0, 1 or 2;
- and
- n is 1 or 2.
Dependencies are inferred from the claim text.