Back to results
US 8,710,057 B2Granted
Imidazo[1,2-B]pyridazine and pyrazolo[1 .5-A]pyrimidine derivatives and their use as protein kinase inhibitors
AssigneeTolero Pharmaceuticals, Inc.
InventorsDavid J. Bearss, Xiao-Hui Liu, Hariprasad Vankayalapati, Yong Xu
Life of this patent
Estimating the term…
Abstract
The present invention provides protein kinase inhibitors comprising imidazo[1,2-b]pyridazine and pyrazolo[1,5-a]pyrimidine compounds of the following structure (I) and (II): or a stereoisomer, prodrug or pharmaceutically acceptable salt thereof, wherein R, R1, R2 and X are as defined herein. Compositions and methods for using the same in the treatment of cancer and other Pim kinase-associated conditions are also disclosed.
Claims16
A compound having a structure according to structure (I) below:
- including stereoisomers, tautomers, prodrugs and pharmaceutically acceptable salts thereof, where:
- X is NH, S, O, SO or SO2;
- R is H, —OH, halo, alkyl, haloalkyl, alkoxy or haloalkoxy;
- R1 has the following structure:
- where R1′ is —CF3 and m is 1, 2, 3, 4 or 5;
- and
- R2 is —(CH2)n-cyclopropyl, —(CH2)n-cyclopentyl or —(CH2)n-cyclohexyl, where n is 0, 1, 2, 3 or 4, and wherein the —(CH2)n-cyclopropyl, —(CH2)n-cyclopentyl and —(CH2)n-cyclohexyl moieties are each optionally substituted with one or more substituents selected from hydroxyalkyl.
4 more elements
Dependencies are inferred from the claim text.