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US 8,710,052 B2Granted
Compounds and compositions for treating chemical warfare agent-induced injuries
AssigneeHydra Biosciences, Inc.
InventorJayhong A. Chong
Life of this patent
Estimating the term…
Abstract
Compounds and compositions for treating injuries caused by exposure to chemical warfare agents are described herein.
Claims15
A method of treating an injury to the skin or respiratory tract on a subject in need thereof resulting from exposure to a chemical warfare agent, the method comprising administering to a subject an effective amount of a compound of Formula (IV), or a salt thereof:
- wherein,
- each of R1 and R2 is independently C1-C6 alkyl, C2-C6 alkenyl, or C2-C6 alkynyl, each of which is optionally substituted with 1-4 R5;
- L is NR6SO2, SO2NR6, OC(O)NR6, NR6C(O)O, NR6C(O)NR6, NR6C(O), C(O)NR6, O, C(O), S, S(O), S(O)2, NR6, CH2, cyclyl, aryl, heterocyclyl, or heteroaryl;
- R3 is cyclyl, heterocyclyl, aryl, heteroaryl, each of which is optionally substituted with 1-4 R7;
- each R5 is independently halo, hydroxyl, alkoxy, amino, alkylamino, dialkylamino, cyano, nitro, amido, alkylamido, dialkylamido, thioyl, sulfonyl, cyclyl, heterocyclyl, aryl, or heteroaryl;
- each R6 is independently H, C1-C6 alkyl, arylalkyl, S(O)alkyl, acetyl, amidyl, or S(O)H;
- each R7 is independently C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, cyclyl, heterocyclyl, aryl, heteroaryl, halo, hydroxyl, alkoxy, aryloxy, arylalkoxy, amino, akylamino, dialkylamino, thioyl, alkylthioyl, sulfonyl, sulfonamidyl, amido, urea, sulfonylurea, hydroxyl alkoxyl, alkoxy alkoxyl, acyl, nitro, cyano, each of which is independently substituted with 1-3 R8;
- each R8 is independently C1-C6 alkyl, C2-C6 alkenyl, or C2-C6 alkynyl, halo, hydroxyl, alkoxy, aryloxy, amino, akylamino, dialkylamino, thioyl, sulfonyl, sulfonamidyl, amido, urea, sulfonylurea acyl, nitro, cyano, cyclyl, heterocyclyl, aryl, or heteroaryl;
- each of m and n is independently 0, 1, 2, 3, 4, 5, or 6;
- each R9 is independently H, C1-C6 alkyl, C2-C6 alkenyl, or C2-C6 alkynyl, halo, hydroxyl, alkoxy, aryloxy, arylalkoxy, amino, akylamino, dialkylamino, thioyl, alkylthioyl, sulfonyl, sulfonamidyl, amido, urea, sulfonylurea, acyl, nitro, cyano, each of which is independently substituted with 1-3 R8.
7 more elements
A method of treating an injury to the skin or respiratory tract on a subject in need thereof resulting from exposure to a chemical warfare agent, the method comprising administering to a subject an effective amount of a compound of Formula (VI), or a salt thereof
- wherein,
- R1 is C1-C6 alkyl, C2-C6 alkenyl, or C2-C6 alkynyl, each of which is optionally substituted with 1-4 R5;
- R2 is C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, or cycyl, each of which is optionally substituted with 1-4 R5;
- L is NR6SO2, SO2NR6, OC(O)NR6, NR6C(O)O, NR6C(O)NR6, NR6C(O), C(O)NR6, O, C(O), S, S(O), S(O)2, NR6, CH2, cyclyl, aryl, heterocyclyl, or heteroaryl;
- R3 is cyclyl, heterocyclyl, aryl, or heteroaryl, each of which is optionally substituted with 1-4 R7;
- each R5 is independently halo, hydroxyl, alkoxy, amino, alkylamino, dialkylamino, cyano, nitro, amido, alkylamido, dialkylamido, thioyl, sulfonyl, cyclyl, heterocyclyl, aryl, or heteroaryl;
- each R6 is independently H, C1-C6 alkyl, arylalkyl, S(O)alkyl, acetyl, amidyl, or S(O)H;
- each R7 is independently C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, cyclyl, heterocyclyl, aryl, heteroaryl, halo, hydroxyl, alkoxy, aryloxy, arylalkoxy, amino, akylamino, dialkylamino, thioyl, alkylthioyl, sulfonyl, sulfonamidyl, amido, urea, sulfonylurea, hydroxyl alkoxyl, alkoxy alkoxyl, acyl, nitro, cyano, each of which is independently substituted with 1-3 R8;
- each R8 is independently C1-C6 alkyl, C2-C6 alkenyl, or C2-C6 alkynyl, halo, hydroxyl, alkoxy, aryloxy, amino, akylamino, dialkylamino, thioyl, sulfonyl, sulfonamidyl, amido, urea, sulfonylurea acyl, nitro, cyano, cyclyl, heterocyclyl, aryl, or heteroaryl;
- each R9 is independently H, C1-C6 alkyl, C2-C6 alkenyl, or C2-C6 alkynyl, halo, hydroxyl, alkoxy, aryloxy, arylalkoxy, amino, akylamino, dialkylamino, thioyl, alkylthioyl, sulfonyl, sulfonamidyl, amido, urea, sulfonylurea, acyl, nitro, cyano, each of which is independently substituted with 1-3 R8;
- each m and n are independently 0, 1, 2, 3, 4, 5, or 6.
8 more elements
Dependencies are inferred from the claim text.