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US 8,710,050 B2Granted
Di and tri- substituted oxathiazine derivatives, method for the production, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof
AssigneeSanofi
InventorsThomas Boehme, Christian Engel, Stefan Guessregen, Torsten Haack, Kurt Ritter, Georg Tschank
Life of this patent
Estimating the term…
Abstract
The invention relates to compounds of formula (I) and to the physiologically compatible salts thereof. Said compounds are suitable, for example, for treating hyperglycemia.
Claims12
A compound of the formula I
- in which
- L is R1, —CH(R10)(R11);
- R10, R11 are each independently H, F, Cl, Br, I, OH, CF3, CHF2, CH2F, NO2, CN, OCF3, OCHF2, O—(C1-C6)-alkyl, (C1-C6)-alkyl, NH2, NH(C1-C6)-alkyl, N((C1-C6)-alkyl)2, COOH, COO—(C1-C6)-alkyl, CONH2, CONH(C1-C6)-alkyl, CON((C1-C6)-alkyl)2, SF5, (C1-C6)-alkylene-(R6), (C3-C8)-cycloalkylene-(R6), (C1-C6)-alkylene-(C3-C8)-cycloalkylene-(R6), (C6-C10)-aryl, (C 1-C6)-alkylene-(C6-C10)-aryl, -(C6-C10)-heteroaryl, (C1-C6)-alkylene-(C6-C10)-heteroaryl;
- where the aryl radical or heteroaryl radical may be mono- to trisubstituted by F, Cl, Br, I, OH, CF3, CHF2, CH2F, NO2, CN, OCF3, OCHF2, O—(C1-C6)-alkyl, (C1-C6)-alkyl, NH2, NH(C1-C6)-alkyl, N((C1-C6)-alkyl)2, SO2—CH3, SO2—NH2, SO2—NH(C1-C6)-alkyl, SO2—N((C1-C6)-alkyl)2, COOH, COO—(C1-C6)-alkyl, CONH2, CONH(C1-C6)-alkyl, CON((C1-C6)-alkyl)2, SF5;
- R6 is OH, CF3, CHF2, CH2F, NO2, CN, OCF3, OCHF2, O—(C1-C6)-alkyl, (C1-C6)-alkyl, NH2, NH(C1-C6)-alkyl, N((C1-C6)-alkyl)2, SO2—CH3, SO2—NH2, SO2—NH(C1-C6)-alkyl, SO2—N((C1-C6)-alkyl)2, COOH, COO—(C1-C6)-alkyl, CONH2, CONH(C1-C6)-alkyl, CON((C1-C6)-alkyl)2, SF5;
- R1 is (C6-C10)-aryl, (C3-C8)-cycloalkyl, (C3-C8)-carbocyclyl,
- where the aryl radical, cycloalkyl radical or carbocyclyl radical may be mono- to trisubstituted by F, Cl, Br, I, OH, CF3, CHF2, CH2F, NO2, CN, OCF3, OCHF2, O—(C1-C6)-alkyl, (C1-C6)-alkyl, NH2, NH(C1-C6)-alkyl, N((C1-C6)-alkyl)2, SO2—CH3, SO2—NH2, SO2—NH(C1-C6)-alkyl, SO2—N((C1-C6)-alkyl)2, COOH, COO—(C1-C6)-alkyl, CONH2, CONH(C1-C6)-alkyl, CON((C1-C6)-alkyl)2, SF5;
- R2, R3, R4 are each independently (C1-C6)-alkyl, CF3, CHF2, CH2F, (C1-C6)-alkylene-OH, (C1-C6)-alkylene-O—(C1-C6)-alkyl, (C1-C6)-alkylene-O—(C6-C10)-aryl, or R2 and R3 together with the carbon atom to which they are bonded form a 3-8-membered saturated carbocyclic or heterocyclic ring which may contain up to 2 further heteroatoms from the group of N, O and S;
- and pharmaceutically compatible salts thereof.
6 more elements
Dependencies are inferred from the claim text.