5-HT3 receptor modulators, methods of making, and use thereof

A compound having the following formula:

• wherein:
• X is CH or N;
• each R1 is independently selected from the group consisting of H, halogen, —OR4, or C1-C6 alkyl, wherein C1-C6 alkyl is optionally substituted with from 1 to 3 substituents independently selected at each occurrence thereof from C1-C3 alkyl, halogen, —CN, —OR7, —NR7R8, and phenyl which is optionally substituted 1-3 times with halogen, C1-C4 alkyl, C1-C4 haloalkyl, C1-C4 alkoxy, —CN, —OR7, or —NR7R8;
• R2 is H;
• R4 is H, C1-C4 alkyl, C1-C4 haloalkyl, C1-C4 alkoxyalkyl, C3-C6 cycloalkyl, C4-C7 cycloalkylalkyl, —C(O)R6, phenyl, or benzyl, wherein phenyl or benzyl is optionally substituted 1 to 3 times with halogen, cyano, C1-C4 alkyl, C1-C4 haloalkyl, or C1-C4 alkoxy;
• R6 is C1-C4 alkyl, C1-C4 haloalkyl, or phenyl;
• R7 and R8 are each independently H, C1-C4 alkyl, C1-C4 haloalkyl, C1-C4 alkoxyalkyl, C3-C6 cycloalkyl, C4-C7 cycloalkylalkyl, —C(O)R6, phenyl, or benzyl, wherein phenyl or benzyl is optionally substituted from 1 to 3 times with a substituent selected independently at each occurrence thereof from the group consisting of halogen, cyano, C1-C4 alkyl, C1-C4 haloalkyl, and C1-C4 alkoxy;
• n is 1 or 2;
• and
• p is 0, 1, 2, or 3;
• or an oxide thereof or a pharmaceutically acceptable salt thereof.