TRPM8 antagonists and their use in treatments
AssigneeAmgen Inc.
InventorsJian J. Chen, Daniel B. Horne, Matthew R. Kaller, Vu Van Ma
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Abstract
Compounds of Formula I are useful as antagonists of TRPM8. Such compounds are useful in treating a number of TRPM8 mediated disorders and conditions and may be used to prepare medicaments and pharmaceutical compositions useful for treating such disorders and conditions. Examples of such disorders include, but are not limited to, migraines and neuropathic pain. Compounds of Formula I have the following structure: where the definitions of the variables are provided herein.
Claims40
A compound having the formula
- or a pharmaceutically-acceptable salt thereof.
A compound having the formula
- or a pharmaceutically-acceptable salt thereof.
A compound having the formula
- or a pharmaceutically-acceptable salt thereof.
A compound having the formula
- or a pharmaceutically-acceptable salt thereof.
A compound having the formula
- or a pharmaceutically-acceptable salt thereof.
A compound having the formula
- or a pharmaceutically-acceptable salt thereof.
A compound having the formula
- or a pharmaceutically-acceptable salt thereof.
A compound having the formula
- or a pharmaceutically-acceptable salt thereof.
A compound having the formula
- or a pharmaceutically-acceptable salt thereof, a tautomer thereof, or a pharmaceutically-acceptable salt of the tautomer.
A compound having the formula
- or a pharmaceutically-acceptable salt thereof, a tautomer thereof, or a pharmaceutically-acceptable salt of the tautomer.
Dependencies are inferred from the claim text.