Pharmaceutical composition comprising gabapentin or an analogue thereof and an α-aminoamide and its analgesic use

A method for treating neuropathic pain in a mammal in need thereof, comprising administering to the mammal a therapeutically effective dose of a pharmaceutical composition comprising:

• gabapentin or pregabalin, or a pharmaceutically acceptable acid addition salt with inorganic or organic acids thereof;
• and
• an α-aminoamide selected from the group consisting of:
• (S)-(+)-2-[4-(2-fluorobenzyloxy)benzylamino]-propanamide;
• (R)-(−)-2-[4-benzyloxybenzylamino]-3-phenyl-N-methylpropanamide;
• (S)-(+)-2-[4-(3-fluorobenzyloxy)-benzylamino]-N-methyl-propanamide;
• and
• either as an isolated optically active isomer or as a racemic mixture thereof, or a pharmaceutically acceptable acid addition salt with inorganic or organic acids of the isolated optically active isomer or racemic mixture,
• wherein the α-aminoamide and gabapentin or pregabalin or the pharmaceutically acceptable acid addition salts thereof are present in a ratio based on a fraction of their respective ED50 values, wherein the ratio ranges from about 1:1 to about 30:1 or from about 1:1 to about 1:30, respectively.