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US 8,710,039 B2Granted
Therapeutic compositions and methods
AssigneeThe Penn State Research Foundation
InventorsGong Chen, Yanming Wang, Pingxin Li, Jing Hu, Shu Wang, Yuji Wang
Life of this patent
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Abstract
PAD4 inhibitory compositions and methods for their use in treatment of cancer and autoimmune disease are provided according to embodiments of the present invention.
Claims8
A composition comprising a substance having the structural formula selected from the group consisting of:
- where n is 1 or 2;
- X is halogen;
- each Y is independently H, halogen, an O-linked aliphatic substituent or an N-linked aliphatic substituent;
- R1 is an aromatic substituent;
- and R2 is an aliphatic or aromatic substituent;
- a salt, stereoisomer, hydrate, amide or ester thereof;
- and a mixture of any two or more thereof.
4 more elements
Dependencies are inferred from the claim text.