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US 8,710,037 B2Granted
Pyrrolidine derivatives, pharmaceutical compositions containing the same, and methods of using the same
AssigneeChiesi Farmaceutici S.p.A.
InventorsEleonora Ghidini, Anna Maria Capelli
Life of this patent
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Abstract
Novel anti-inflammatory and antiallergic compounds of the glucocorticosteroid series according to formulae (I) and (I′) are effective for the prevention and/or treatment of diseases in which the number, activity, and movement of inflammatory cells is implicated.
Claims24
A compound of formula (I):
- wherein:
- R1 is (CH2)n—V—(CH2)n′—R4, wherein:
- n and n′ are independently 0 or 1;
- V is absent or is —O—, —S—, or —OC(O) —;
- and
- R4 is —H, —OH, —CN, halogen, or (C1-C6)alkyl, in which one or more of the hydrogen atoms of the alkyl group may be optionally substituted by one or more groups selected from the group consisting of oxo, —CN, —SH, and halogen;
- R2 is (CH2)m—R6, wherein:
- m=0 or an integer from 1 to 4;
- and
- R6 is aryl or heteroaryl, each of which may be optionally substituted by one or more groups selected from the group consisting of oxo, —OH, —CN, —COOH, (C1-C6)alkoxy, (C1-C6)alkyl, (C1-C6)haloalkyl, and halogen;
- or a pharmaceutically acceptable salt thereof.
8 more elements
Dependencies are inferred from the claim text.