Cell proliferation inhibitor
AssigneeNational University Corporation Nagoya University
InventorsTakashi Takahashi, Tomoya Yamaguchi, Shuta Tomida
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Abstract
The present inventors revealed a TTF-1-specific oncogenic process by elucidating the molecular mechanism regulated by the master regulatory factor TTF-1. The present inventors focused on the elucidation of the essence of the lineage-specific survival signal which is a novel canceration signal. Thus, the present inventors found that the expression of ROR1, which is a receptor tyrosine kinase, is induced by the master regulatory factor TTF-1, and demonstrated the presence of a characteristic canceration signal transduction system.
Claims6
A method for treating or preventing cancer, which comprises the step of administering to a subject having a TTF-1+ROR1+ cell population a nucleic acid that inhibits ROR1 gene expression.
Dependencies are inferred from the claim text.