Method for treating oncological diseases
AssigneeCLS Therapeutics Limited
InventorsDmitry Dmitrievich Genkin, Georgy Viktorovich Tets, Viktor Veniaminovich Tets
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Abstract
A method to treat cancer and other malignant diseases, said method comprising parenterally administering an agent which destroys blood extracellular DNA into the systemic circulation of a cancer patient to slow down cancer growth. The agent is embodied in the form of a DNase enzyme and, more particularly, as a DNase I enzyme. Doses from 50,000-250,000,000 Kunitz units/day are administered for 5-360 days.
Claims4
A method of treating a cancer in a patient in need thereof, wherein the cancer is accompanied with elevation of blood extracellular DNA level, said method comprising parenterally administering to the patient a DNase enzyme in doses and regiments which provide blood plasma DNA-hydrolytic activity to exceed 150 Kunitz units per liter of plasma during more than 12 hours within 24 hours, and further comprising parenterally administering to said patient an anti-DNA antibody.
A method of treating a cancer in a patient in need thereof, wherein said cancer is malignant melanoma and is accompanied with elevation of blood extracellular DNA level, said method comprising parenterally administering to the patient a DNase enzyme in doses and regiments which provide blood plasma DNA-hydrolytic activity to exceed 150 Kunitz units per liter of plasma during more than 12 hours within 24 hours.
Dependencies are inferred from the claim text.