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US 8,710,011 B2Granted
Cosmetic or pharmaceutical peptides containing uncoded amino acids and their use in the treatment and/or care of the skin, mucous membranes, or scalp
AssigneeLipotec, S.A.
InventorsNuria Garcia Sanz, Wim Van Den Nest, Cristina Carreno Serraima, Antonio Ferrer Montiel, Juan Cebrian Puche, Nuria Alminana Domenech
Life of this patent
Estimating the term…
Abstract
Peptides of general formula (I): R1-Wp-Xn-AA1-AA2-AA3-AA4-Ym-R2 their stereoisomers, mixtures thereof, and/or their cosmetically or pharmaceutically acceptable salts, a method of preparation, cosmetic or pharmaceutical compositions containing them and their use for the treatment, prevention and/or care of conditions, disorders and/or diseases of the skin, mucous membranes and/or scalp.
Claims25
A peptide of general formula (I)
- R1-Wp-Xn-AA1-AA2-AA3-AA4-Ym-R2 (I)
- its stereoisomers, mixtures thereof, and/or its cosmetically or pharmaceutically acceptable salts, wherein at least one of the amino acids AA1, AA2 and AA4 is uncoded, and in that:
- AA1 is selected from the group consisting of -Arg-, -Phg- and -Nle- or is a bond;
- AA2 is selected from the group consisting of -Ala-, -Phg-, -Cit- and -Nle-;
- AA3 is selected from the group consisting of -Trp-, -Val- and -Tyr-;
- AA4 is selected from the group consisting of -Phg- and -Gly-;
- W, X and Y are independently selected from the group consisting of coded or uncoded amino acids;
- p, n and m range between 0 and 1;
- R1 is selected from the group consisting of H, substituted or unsubstituted non-cyclic aliphatic group, substituted or unsubstituted alicyclyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted heteroarylalkyl, substituted or unsubstituted aryl, substituted or unsubstituted aralkyl and R5—CO;
- R2 is selected from the group consisting of —NR3R4, —OR3 and —SR3;
- wherein R3 and R4 are independently selected from the group consisting of H, substituted or unsubstituted non-cyclic aliphatic group, substituted or unsubstituted alicyclyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted heteroarylalkyl, substituted or unsubstituted aryl and substituted or unsubstituted aralkyl;
- wherein R5 is selected from the group consisting of H, substituted or unsubstituted non-cyclic aliphatic group, substituted or unsubstituted alicyclyl, substituted or unsubstituted aryl, substituted or unsubstituted aralkyl, substituted or unsubstituted heterocyclyl and substituted or unsubstituted heteroarylalkyl;
- and provided that when AA1 is a bond, AA2 is -Phg- and AA3 is -Tip-.
10 more elements
Dependencies are inferred from the claim text.