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US 8,710,010 B2Granted
Peptides useful in the treatment and/or care of skin, mucous membranes, scalp and/or hair and their use in cosmetic or pharmaceutical compositions
AssigneeLipotec, S.A.
InventorsWim Van Den Nest, Nuria Almiñana Domenech, Juan Cebrián Puche, Cristina Carreño Serraïma
Life of this patent
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Abstract
Peptides with general formula (I): R1-AA1-AA2-AA3-AA4-R2 its stereoisomers, mixtures thereof, and its cosmetically or pharmaceutically acceptable saits, a method of preparation, cosmetic or pharmaceutical compositions containing them and their use for the treatment and/or care of conditions, disorders and/or pathologies of the skin, mucous membranes, scalp and/or hair.
Claims18
A peptide with general formula (I)
- R1-AA2-AA3-AA4-R2 (I)
- its stereoisomers, mixtures thereof, or its cosmetically or its pharmaceutically acceptable salts comprising:
- AA1 is selected from the group consisting of -Lys-, -Orn-, -Dab-, -Dpr-, -Agl-, -3,4-dehydrolysine and -4,5-dehydrolysine;
- AA2 is -Ala-;
- AA3 is selected from the group consisting of -Asp-, -Ala-, -Asn-, -Glu- and -Pro-;
- AA4 is -His-;
- R1 is selected from the group consisting of H, substituted or unsubstituted non-cyclic aliphatic group, substituted or unsubstituted alicyclyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted heteroarylalkyl, substituted or unsubstituted aryl, substituted or unsubstituted aralkyl and R5—CO—;
- and
- R2 is selected from the group consisting of —NR3R4, —OR3 and —SR3;
- where R3 and R4 are independently selected from the group consisting of H, unsubstituted noncyclic aliphatic group, substituted or unsubstituted alicycyl, unsubstituted heterocyclyl, unsubstituted heteroarylalkyl, substituted or unsubstituted aryl, and unsubstituted aralkyl;
- and
- where R5 is selected from the group consisting of H, substituted or unsubstituted noncyclic aliphatic group, substituted or unsubstituted alicyclyl, substituted or unsubstituted aryl, substituted or unsubstituted aralkyl, substituted or unsubstituted heterocyclyl and substituted or unsubstituted heteroarylalkyl, and
- wherein when R1 or R5 is a substituted non-cyclic aliphatic group, each substituent of said substituted non-cyclic aliphatic group is selected from the group consisting of hydroxyl , C1-C4 alcoxyl, C1-C4 oxycarbonyl, halogen, cyano, nitro, azido, C1-C4 alkylsulfonyl, thiol, alkylthio, aryloxyl, and -NRb(C=NRb)NRbRc, where Rb and Rc are independently selected from the group consisting of H, C1-C4 alkyl, C2-C4 alkenyl, C2-C4 alkynyl, C3-C10 cycloalkyl, C6-C18 aryl, C7-C17 aralkyl, and 3-10-membered-heterocyclyl.
10 more elements
A method for the treatment and/or care of skin, mucous membranes, scalp and/or hair, wherein the treatment and/or care provides photoprotection and/or protection of cell DNA of skin, mucous membranes, scalp and/or hair, the method comprising administering a peptide with general formula (I),
- R1-AA1-AA2-AA3-AA4-R2 (I)
- its stereoisomers, mixtures thereof, or its cosmetically or its pharmaceutically acceptable salts to skin, mucous membranes, scalp and/or hair, wherein:
- AA1 is selected from the group consisting of -Lys-, -Orn-, -Dab-, -Dpr-, -Agl-, -3,4-dehydrolysine and -4,5-dehydrolysine;
- AA2 is -Ala-;
- AA3 is selected from the group consisting of -Asp-, -Ala-, -Asn-, -Glu- and -Pro-;
- AA4 is -His-;
- R1 is selected from the group consisting of H, substituted or unsubstituted non-cyclic aliphatic group, substituted or unsubstituted alicyclyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted hetero aryl alkyl , substituted or unsubstituted aryl, substituted or unsubstituted aralkyl and R5—CO—;
- and
- R2 is selected from the group consisting of —NR3R4, —OR3 and —SR3;
- where R3 and R4 are independently selected from the group consisting of H, substituted or unsubstituted non-cyclic aliphatic group, substituted or unsubstituted alicycyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted heteroarylalkyl, substituted or unsubstituted aryl, and substituted or unsubstituted aralkyl;
- where R5 is selected from the group consisting of H, substituted or unsubstituted noncyclic aliphatic group, substituted or unsubstituted alicyclyl, substituted or unsubstituted aryl, substituted or unsubstituted aralkyl, substituted or unsubstituted heterocyclyl and substituted or unsubstituted heteroarylalkyl.
8 more elements
A method for the treatment and/or care of skin, mucous membranes, scalp and/or hair, wherein the treatment and/or care reduces and/or postpones signs of aging, photoaging, cellulite and/or body odor, the method comprising administering a peptide with general formula (I),
- R1-AA1-AA2-AA3-AA4-R2 (I)
- its stereoisomers, mixtures thereof, or its cosmetically or its pharmaceutically acceptable salts to skin, mucous membranes, scalp and/or hair, wherein:
- AA1 is selected from the group consisting of -Lys-, -Orn-, -Dab-, -Dpr-, -Agl-, -3,4-dehydrolysine and -4,5-dehydrolysine;
- AA2 is -Ala-;
- AA3 is selected from the group consisting of -Asp-, -Ala-, -Asn-, -Glu- and -Pro-;
- AA4 is -His-;
- R1 is selected from the group consisting of H, substituted or unsubstituted non-cyclic aliphatic group, substituted or unsubstituted alicyclyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted hetero aryl alkyl , substituted or unsubstituted aryl, substituted or unsubstituted aralkyl and R5—CO—;
- and
- R2 is selected from the group consisting of —NR3R4, —OR3 and —SR3;
- where R3 and R4 are independently selected from the group consisting of H, substituted or unsubstituted non-cyclic aliphatic group, substituted or unsubstituted alicycyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted heteroarylalkyl, substituted or unsubstituted aryl, and substituted or unsubstituted aralkyl;
- where R5 is selected from the group consisting of H, substituted or unsubstituted noncyclic aliphatic group, substituted or unsubstituted alicyclyl, substituted or unsubstituted aryl, substituted or unsubstituted aralkyl, substituted or unsubstituted heterocyclyl and substituted or unsubstituted heteroarylalkyl.
8 more elements
Dependencies are inferred from the claim text.