Neuronal differentiation-inducing peptide and use thereof
AssigneeToagosei Co., Ltd.
InventorsTetsuhiko Yoshida, Nahoko Kobayashi
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Abstract
A neuronal differentiation inducer provided by the present invention contains an artificially synthesized peptide which includes an amino acid sequence constituting a signal peptide in amyloid precursor protein (APP), or a partial sequence of the amino acid sequence constituting this signal peptide.
Claims14
A composition for inducing neuronal differentiation of at least one type of stem cell into a nerve cell, the composition comprising:
- an artificially synthesized peptide consisting of:
- (A) a signal peptide in amyloid precursor protein (APP), or an N-terminal side partial amino acid sequence that is part of the amino acid sequence of the signal peptide and is composed of at least six consecutive amino acid residues counting from the N-terminal amino acid residue of the sequence, or a C-terminal side partial amino acid sequence that is part of the amino acid sequence of the signal peptide and is composed of at least five consecutive amino acid residues counting from the C-terminal amino acid residue of the sequence, wherein the signal peptide is the amino acid sequence of SEQ ID NO:
- 2 or SEQ ID NO:
- 3;
- and
- (B) an amino acid sequence constituting a protein transduction domain, wherein the protein transduction domain is linked directly or via a linker sequence to (A) the signal peptide or the N-terminal side or C-terminal side partial amino acid sequence of the signal peptide, wherein the linker sequence is composed of one to nine glycine residues and/or serine residues;
- and
- at least one pharmaceutically acceptable carrier.
An artificially synthesized peptide capable of inducing neuronal differentiation of at least one type of stem cell into a nerve cell, the artificially synthesized peptide consisting of:
- (A) a signal peptide in amyloid precursor protein (APP), or an N-terminal side partial amino acid sequence that is part of the amino acid sequence of the signal peptide and is composed of at least six consecutive amino acid residues counting from the N-terminal amino acid residue of the sequence, or a C-terminal side partial amino acid sequence that is part of the amino acid sequence of the signal peptide and is composed of at least five consecutive amino acid residues counting from the C-terminal amino acid residue of the sequence, wherein the signal peptide is the amino acid sequence of SEQ ID NO:
- 2 or SEQ ID NO:
- 3;
- and
- (B) an amino acid sequence constituting a protein transduction domain, wherein the protein transduction domain is linked directly or via a linker sequence to (A) the signal peptide or the N-terminal side or C-terminal side partial amino acid sequence of the signal peptide, wherein the linker sequence is composed of one to nine glycine residues and/or serine residues.
Dependencies are inferred from the claim text.