PEGylated, extended insulins
AssigneeNovo Nordisk A/S
InventorsPeter Madsen, Thomas Børglum Kjeldsen, Tina Møller Tagmose, Palle Jakobsen
Life of this patent
Estimating the term…
Abstract
PEGylated, extended insulins are insulins which, compared with human insulin, has one or more extensions extended from the A1, B1, A21 and/or B30 position(s), said extension(s) consist(s) of amino acid residue(s) and wherein a PEG moiety, via a linker, is attached to one or more of the amino acid residues in the extension(s). PEG is polyethyleneglycol. Such PEGylated, extended insulins have higher bioavailability and a longer time-action profile than regular insulin and are in particular suited for pulmonary administration and can, conveniently, be used to treat diabetes.
Claims15
A PEGylated insulin analogue having one or more PEG-containing extensions extending from one or more of the A1, B1, A21 and/or B30 position(s) as compared to human insulin, wherein said extension(s) consist(s) of one or more amino acid residue(s), added either C- or N-terminally to the A- or B-chain of human insulin, to which the PEG moiety is attached via a linker, with the proviso that the parent insulin analogue contains only one lysine residue.
Dependencies are inferred from the claim text.