Pharmaceutical treatment process using chitosan or derivative thereof
AssigneeArchimedes Development Limited
InventorsMichael Leane, Alan Smith, Lisbeth Illum
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Abstract
The present invention provides a solid composition for oral administration comprising: (i) a drug compound; (ii) chitosan or a derivative thereof or a salt of chitosan or salt of a derivative of chitosan; and (iii) an organic acid. Preferably the drug compound is a polar molecule having a molecular weight of 1 KDa or less, a peptide, a protein or a polysaccharide. The compositions of the invention provide enhance absorption of the drug compound.
Claims21
A process for enhancing absorption of a drug compound by a mammalian patient to which the drug compound is orally administered, wherein the process comprises orally administering to the patient a solid composition comprising a solid mixture comprising the drug compound that is a polar molecule having a molecular weight of 1 KDa or less, a peptide, a protein or a polysaccharide, and chitosan or a derivative thereof or a salt of chitosan or a salt of a derivative of chitosan, and an organic acid, wherein at least a part of the acid is in the form of an agglomerate, and wherein the acid and the chitosan or a derivative thereof or a salt of chitosan or a salt of a derivative of chitosan are present in a weight ratio of from 10:1 to 1:1, whereby absorption of the drug compound is enhanced within the gastrointestinal tract of the mammalian patient.
Dependencies are inferred from the claim text.