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AssigneeThe Johns Hopkins University
InventorsDavid H. Gracias, Timothy Gar-Ming Leong, Hongke Ye
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The present invention relates to a nanoscale or microscale particle for encapsulation and delivery of materials or substances, including, but not limited to, cells, drugs, tissue, gels and polymers contained within the particle, with subsequent release of the therapeutic materials in situ, methods of fabricating the particle by folding a 2D precursor into the 3D particle, and the use of the particle in in-vivo or in-vitro applications The particle can be in any polyhedral shape and its surfaces can have either no perforations or nano/microscale perforations The particle is coated with a biocompatible metal, e g gold, or polymer e g parvlene, layer and the surfaces and hinges of the particle are made of any metal or polymer combinations.
A method for treating a condition comprising introducing into a subject in need of treatment at least one three-dimensional particle or biocapsule encapsulating a composition, wherein the three-dimensional particle or biocapsule comprises a plurality of two-dimensional faces capable of self-folding to form a hollow interior, wherein a size of the particle or biocapsule is microscale or nanoscale, and wherein the plurality of two-dimensional faces comprise a folding hinge between two adjacent faces and a locking or sealing hinge on an edge of a two-dimensional face, wherein the folding hinge between two adjacent faces has a width that is about twice a width of the locking or sealing hinge on an edge, wherein the plurality of two-dimensional faces comprising the three-dimensional particle or biocapsule are permanently held together by solid hinges;
Dependencies are inferred from the claim text.