Drug comprising as the active ingredient proliferative vector containing survivin promoter
AssigneeKenichiro Kosai
InventorsKenichiro Kosai, Jyunichi Kamizono, Satoshi Nagano
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Abstract
It is intended to provide a drug to be used in gene therapy which specifically targets abnormal cells such as tumor cells and destroys the same for healing. Namely, a drug comprising, as the active ingredient, a proliferative vector which contains a Survivin promoter proliferating depending on the expression of Survivin. The drug may be used in order to treat tumor. In this drug, use may be made of an adenovirus as the vector. In the adenovirus of this drug, an endogenous promoter of an E1A domain may be substituted with a Survivin promoter.
Claims4
A method for treating a subject having a malignant tumor with high survivin expression, the method comprising directly administering to the malignant tumor an effective amount of a pharmaceutical composition comprising a replication competent adenoviral vector containing an adenoviral genome that includes an E1A gene in which the E1A gene promoter is replaced by the survivin promoter and the survivin promoter is operably linked to the E1A gene.
Dependencies are inferred from the claim text.