Method for using directing cells for specific stem/progenitor cell activation and differentiation
AssigneeBiogencell, Ltd.
InventorYael Porat
Life of this patent
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Abstract
A method is provided, including obtaining a population of antigen-presenting cells, enriching a population of stem/progenitor cells within a larger population of cells, activating the population of antigen-presenting cells and, following the activating, inducing at least one process selected from the group consisting of: differentiation, expansion, activation, secretion of a molecule, and expression of a marker, by exposing the enriched stem/progenitor cell population to the population of antigen-presenting cells. Other applications are also described.
Claims22
A composition of matter comprising an isolated population of at least 5 million lineage specific precursor/progenitor (LSP) cells comprising a first, a second and a third subpopulation of cells,
- wherein the first subpopulation of cells comprises at least 5.9% of the total LSP cell population and expresses CD304,
- wherein the second subpopulation of cells comprises at least 2.0% of the total LSP cell population and expresses CD34 and CD184, and
- wherein the third subpopulation of cells comprises the remainder of the LSP cell population,
- wherein the third subpopulation of cells comprises a CD309 and CD202b expressing population, and wherein the CD309 and CD202b expressing population comprises at least 0.2% of the total LSP cell population,
- wherein the third subpopulation of cells further comprises a CD31 and VEGFR1 expressing population, and wherein the CD31 and VEGFR1 expressing population comprises at least 2.3% of the total LSP cell population,
- and wherein the third subpopulation of cells further comprises a population of cells that uptake Ac-LDL and express Ulex lectin, and wherein the population of cells that uptake Ac-LDL and express Ulex lectin comprises between 7% and 41.5% of the total LSP cell population.
Dependencies are inferred from the claim text.