DFPase enzymes from Aplysia californica

An isolated polypeptide having organophosphorous hydrolase activity, selected from the group consisting of:

• (a) a polypeptide comprising an amino acid sequence having at least 90% sequence identity to the mature polypeptide of SEQ ID NO:
• 2;
• (b) a polypeptide encoded by a polynucleotide that hybridizes under at least medium-high stringency conditions with (i) the mature polypeptide coding sequence of SEQ ID NO:
• 1, (ii) a DNA sequence comprising the mature polypeptide coding sequence of SEQ ID NO:
• 1, or (iii) a full-length complementary strand of (i) or (ii), wherein medium-high stringency conditions are defined as prehybridization and hybridization at 42° C. in 5×SSPE, 0.3% SDS, 200 μg/ml sheared and denatured salmon sperm DNA, and 35% formamide and a wash three times, each for 15 minutes using 2×SSC, 0.2% SDS at 60° C.;
• and
• (c) a polypeptide encoded by a polynucleotide comprising a nucleotide sequence having at least 90% sequence identity to the mature polypeptide coding sequence of SEQ ID NO:
• 1.