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US 8,709,764 B2Granted
Enzymatic demethylation of flavonoids
AssigneeUniversiteit Gent
InventorsSam Possemiers, Willy Verstraete, Arne Heyerick, Denis De Keukeleire
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Abstract
The invention discloses the demethylation of 5-methoxyflavonoids by bacterial enzymes, the use of these enzymes in the production of phytoestrogens in vitro, and in pharmaceutical compositions in combination with a source of methylated 5-methoxyprenylflavonoids.
Claims2
A method for producing 8-prenylnaringenin in vitro said method comprising the steps of:
- a) providing a first composition comprising an effective amount a bacterial strain selected from the group consisting of Eubacterium limosum LMG P-23546, Eubacterium limosum ATCC 8486, and Peptostreptococcus productus ATCC 27340,
- b) contacting a second composition comprising isoxanthohumol with said first composition so as to allow dealkylation of said isoxanthohumol by said bacterial strain, and
- c) recovering 8-prenylnaringenin produced.
Dependencies are inferred from the claim text.