Methods and compositions for inhibition of neutrophil exocytosis
AssigneeUniversity of Louisville Research Foundation, Inc.
InventorsKenneth R. McLeish, Silvia M. Uriarte, Madhavi J. Rane
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Abstract
Isolated fusion polypeptides are provided that are comprised of a cell-penetrating polypeptide and a SNARE polypeptide aptamer. Further provided are methods for inhibiting neutrophil granule exocytosis that comprise contacting a neutrophil with a fusion polypeptide including a cell-penetrating polypeptide and a SNARE polypeptide aptamer such that the fusion polypeptide enters the neutrophil and inhibits neutrophil granule exocytosis. Also provided are methods for treating a neutrophil-mediated inflammatory disorder by inhibiting SNARE-associated exocytosis in neutrophils.
Claims6
An isolated nucleic acid comprising the sequence of SEQ ID NO:
- 11.
An isolated fusion protein comprising the sequence of SEQ ID NO:
- 12.
An isolated cell comprising a nucleic acid sequence encoding a fusion protein comprising the sequence of SEQ ID NO:
- 12.
Dependencies are inferred from the claim text.