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US 8,709,751 B2Granted
Preparation of isomerically pure substituted cyclohexanols
AssigneeBASF SE
InventorsMelanie Bonnekessel, Klaus Ditrich, Jürgen Däuwel, Achim Sorg, Wolfgang Ladner, Bryan Cooper, Rene Backes
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Abstract
The present invention relates to the preparation of isomerically pure substituted cyclohexanols starting from a mixture of cis/trans substituted cyclohexanols which comprises reacting the cis/trans mixture of a substituted cyclohexanol with a dicarboxylic acid anhydride in the presence of a lipase, to give the trans semi-ester which is separated off from the unreacted substituted cyclohexanol cis isomer.
Claims14
A process for preparing substantially isomerically pure substituted cyclohexanols, comprising:
- (i) reacting a cis/trans mixture of a substituted cyclohexanol with a dicarboxylic acid anhydride in the presence of a lipase to produce a trans semi-ester,
- (ii) separating the trans semi-ester from unreacted substituted cyclohexanol cis isomer, and
- (iii) isolating the substituted cis or trans cyclohexanol,
- wherein said lipase comprises an amino acid sequence having at least 90% sequence identity to SEQ ID NO:
- 2 and has the enzymatic activity of SEQ ID NO:
- 2.
3 more elements
Dependencies are inferred from the claim text.