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US 8,709,744 B2Granted
Manufacturing process for cellular screening substratum, resultant substratum, and method and apparatus for screening
AssigneeCanon Kabushiki Kaisha
InventorsKenji Nishiguchi, Takeshi Miyazaki, Ryoichi Matsuda, Kohei Watanabe
Life of this patent
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Abstract
The present invention provides cellular screening substrata which can be formed in simple processing steps. The cellular screening substrata can be formed which are characterized in that plural cellular screening substances are positioned and immobilized at predetermined positions on a base by micro-droplet discharging means, and plural areas having different cellular screening functions are formed thereon.
Claims24
A process for manufacturing a cellular screening substratum, comprising steps of:
- ejecting a first solution containing a first substance and a second solution containing a second substance from an inkjet head as micro-droplet discharging means onto a base so as to form a plurality of areas where the first and second substances are positioned with different densities, the first and second substances being different cellular screening substances selected from extracellular matrix proteins, antibodies and cytokines and having a reacting group for binding to the base;
- and
- immobilizing the first and second substances onto the base, each via the reacting group, by applying energy selected from the group consisting of radiation and heating to the base after the ejection.
Dependencies are inferred from the claim text.