Methods of diagnosing a plasmodium infection
AssigneesCentre National De La Recherche Scientifique, Universite De Nice Sophia Antipolis, Museum National D'Histoire Naturelle
InventorsChristiane Deregnaucourt, Gérard Lambeau, Carole Guillaume, Joseph Schrevel
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Abstract
The present disclosure provides in vitro methods of diagnosing a Plasmodium infection in a subject. The methods include measuring the serum concentration of at least one secreted phospholipase A2 selected from the group consisting of GIIF, GV and GX sPLA2s, in a blood sample from the subject. The disclosure also relates to a kit for carrying out the disclosed methods and pharmaceutical compositions comprising a recombinant mammalian GIIF, GV or GX sPLA2, or a combination thereof.
Claims13
An in vitro method of diagnosis of a Plasmodium infection in a subject, comprising the following steps:
- a) measuring a serum concentration of at least one secreted phospholipase A2 (sPLA2) selected from the group consisting of GIIF, GV and GX sPLA2s, in a blood sample from said subject,
- b) comparing the serum concentration of GIIF, GV and/or GX sPLA2s obtained in step a) with a reference serum concentration of GIIF, GV and/or GX sPLA2s in subjects not infected with Plasmodium respectively, wherein an increased serum concentration of GIIF, GV and/or GX sPLA2s in said blood sample from said subject compared to the reference serum concentration of GIIF, GV and/or GX sPLA2s in subjects not infected with Plasmodium is indicative that said subject is infected with Plasmodium.
Dependencies are inferred from the claim text.