Biomarkers of gastric cancer and use thereof
AssigneeThe Hong Kong Polytechnic University
InventorsSamuel Chun-Lap Lo, Katie Wing Kei Lam
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Abstract
A set of biomarkers indicative of early gastric cancer and method of diagnosing gastric cancer at an early stage by directing the these biomarkers in a blood sample. Detection of over-expression of one or more protein biomarks in the group consisting albumin, T-kininogen I, α-2-HS glycoprotein, α-1-antitrypsin, afamin and γ-actin and/or detection of under-expression of one or more protein biomarks in the group consisting stress 70 protein, apolipoprotein A-I, apolipoprotein A-IV, transthyretin and murinoglobulin is indicative of the presence of gastric cancer.
Claims22
A method of diagnosing an early onset of gastric cancer in a subject, the method comprising the steps of:
- (a) detecting in a sample from a subject suspected of having an early onset of gastric cancer at least 3-fold over-expression of at least one first protein biomarker selected from the group consisting of albumin, high molecular weight kininogen, α-2-HS glycoprotein, α-1-antitrypsin, afamin and γ-actin;
- (b) detecting in the sample from the subject suspected of having an early onset of gastric cancer at least 3-fold under-expression of at least three second protein biomarkers selected from the group consisting of stress 70 protein, apolipoprotein A-I, apolipoprotein A-IV, transthyretin, and α2-macroglobulin;
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- (c) identifying the subject as having an early onset of gastric cancer upon detecting the at least one first protein biomarker being at least 3-fold over-expressed in the sample when compared to the expression of the same at least first protein biomarker in a control sample and upon detecting at least one of the three second protein biomarkers being at least 3-fold under-expressed in the sample when compared to the expression of the same second protein biomarker in a control sample.
Dependencies are inferred from the claim text.