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US 8,709,721 B2Granted
Fluorescent molecule and method for detecting target nucleic acid
AssigneeRiken
InventorsHiroshi Abe, Yoshihiro Ito, Aya Shibata, Mika Ito
Life of this patent
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AssigneeRiken
InventorsHiroshi Abe, Yoshihiro Ito, Aya Shibata, Mika Ito
Estimating the term…
Provided are a fluorescent on/off switchable compound for a gene analysis, which is highly stable and highly sensitive, and enables amplification and observation of a trace gene signal, and a labeling reagent for detection of a bio-related material, which uses the fluorescent on/off switchable compound. A compound represented by the following formula (I′): wherein X is a hydrogen atom or a carboxylic acid-protecting group, Y is a 2,4-dinitrobenzenesulfonyl group, a 2-cyano-4-nitrobenzenesulfonyl group or a 5-nitropyridin-2-ylsulfonyl group, R1, R2, R3 and R4 are each independently a hydrogen atom, a halogen atom, a hydroxyl group, an alkyl group having a carbon number of 1 to 6, an alkoxy group having a carbon number of 1 to 6, an aryl group having a carbon number of 6 to 10, or a cyano group.
A compound represented by the following formula (I′):
A compound represented by the following formula (I′):
A method of detecting a target nucleic acid sequence, comprising
Dependencies are inferred from the claim text.