Viruses lacking epithelial cell receptor entry
AssigneeMayo Foundation for Medical Education and Research
InventorsRoberto Cattaneo, Vincent H. J. Leonard
Life of this patent
Estimating the term…
Abstract
The document provides nucleic acids, polypeptides, and viruses containing nucleic acids and/or polypeptides. The document also provides methods for using viruses to treat cancer patients. Specifically, the document provides nucleic acid molecules encoding viral hemagglutinin (H) polypeptides, viral H polypeptides, and viruses containing nucleic acids and/or H polypeptides. Such viruses are useful for vaccinations and for treating cancer patients as the viruses are not shed.
Claims17
An isolated polypeptide comprising a hemagglutinin (H) polypeptide amino acid sequence that aligns with the amino acid sequence set forth in SEQ ID NO:1, wherein said H amino acid sequence comprises a serine at the position aligning with position 497 of said amino acid sequence and an alanine at the position aligning with position 543 of said amino acid sequence.
An isolated nucleic acid molecule, wherein said nucleic acid molecule encodes a polypeptide comprising a hemagglutinin (H) polypeptide amino acid sequence that aligns with the amino acid sequence set forth in SEQ ID NO:1, wherein said H amino acid sequence comprises a serine at the position aligning with position 497 of said amino acid sequence and an alanine at the position aligning with position 543 of said amino acid sequence.
Dependencies are inferred from the claim text.