Methods of modulating interleukin-22 and immune response by notch regulators
AssigneeDeutsches Rheuma-Forschungszentrum Berlin
InventorsAlexander Scheffold, Sascha Rutz, Frederick Heinrich
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Abstract
The invention relates to the use of notch regulators for modulating IL-22 production in T-cells, by influencing the activity or activation of the notch signal path. The invention further relates to the use of modulating the immune response, primarily in case of infection reactions. The invention in particular relates to the use for treating illnesses associated with infections. The invention further relates to the use for reducing IL-22 production in T-cells.
Claims19
A method for modulating interleukin-22 (IL-22) production in T helper cells comprising:
- contacting T helper cells with notch regulators selected from the group consisting of inducers of signal-active Notch molecules and/or Notch inhibitors, wherein the interleukin-22 production in said T helper cells is modulated and analyzing IL-22 production by said T helper cells.
A method for generating interleukin-22 (IL-22)-producing T helper cells comprising:
- contacting T helper cells with signal-active Notch molecule inducers and/or signal-active Notch molecules, wherein the T helper cells become interleukin-22-producing T helper cells, and
- analyzing IL-22 production by said T helper cells.
A method of generating interleukin-22-producing T helper cells, comprising:
- contacting T helper cells with signal-active Notch molecules, wherein the Notch signaling pathway is activated, and
- analyzing interleukin-22-production by said T helper cells.
Dependencies are inferred from the claim text.